Fig. 4

Expression of selected RNA biomarkers upon different antibiotic exposure concentrations and times. Heatmaps of KPHS_02000 (A), KPHS_11650 (B), KPHS_33360 (C), and KPHS_20750 (D) biomarkers upon exposure to different concentrations of tigecycline. Heatmaps of 12 RNA biomarkers across exposure duration of tigecycline (E and F). The tmexCD1-toprJ1-negative isolate C11 was indicated as ‘S’, and the tmexCD1-toprJ1-positive isolate RGT40-1 was indicated as ‘R’. 16S rRNA was the reference gene