Fig. 6

RBAST accurately classifies K. pneumoniae isolates. Heatmap of changes in 12 validated RNA biomarkers across tigecycline-susceptible (A) and tmexCD-toprJ-positive tigecycline-resistant (B) K. pneumoniae after tigecycline exposure compared with their own control. Tigecycline-sensitive isolates were indicated as ‘S’, and tmexCD-toprJ-positive tigecycline-resistant isolates were indicated as ‘R’. 16S rRNA was applied as the reference gene