Table 1 Characteristics of the four bacteria species and the resistance rates to the three antibiotics (total n = 175)
Species | Mobile resistance gene | Number of strains | Tigecycline | Omadacycline | Eravacyclin | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC50 (μg/mL) | MIC90 (μg/mL) | R (%) | MIC50 (μg/mL) | MIC90 (μg/mL) | R (%) | MIC50 (μg/mL) | MIC90 (μg/mL) | R (%) | ||||
Escherichia coli | tet(X4) | 52 | 8 | 16 | 98.1 | 32 | > 32 | 94.2 | 4 | 4 | 100 | |
none | 45 | < 0.25 | 0.5 | 6.7 | 2 | 8 | 4.4 | 0.25 | 1 | 11.1 | ||
all | 97 | 2 | 16 | 55.7 | 16 | > 32 | 52.6 | 2 | 4 | 58.8 | ||
Klebsiella pneumoniae | tet(A) | 22 | 2 | 4 | 77.3 | > 32 | > 32 | 90.9 | 2 | 8 | 95.45 | |
none | 4 | < 0.25 | 4 | 50 | 4 | 32 | 25 | 0.5 | 2 | 50 | ||
all | 26 | 1 | 4 | 73.1 | 32 | > 32 | 80.8 | 2 | 8 | 88.5 | ||
Enterobacter cloacae | tet(A) | 5 | 4 | 4 | 100 | 32 | > 32 | 100 | 4 | 8 | 100 | |
none | 13 | 0.25 | 0.5 | 0 | 4 | 16 | 15.4 | 0.5 | 1 | 23.1 | ||
all | 18 | 0.5 | 4 | 27.8 | 4 | > 32 | 38.9 | 0.5 | 4 | 44.4 | ||
Acinetobacter spp. | none/all | 34 | 1 | 4 | - | 8 | 32 | - | 2 | 4 | - | |