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Fig. 2 | One Health Advances

Fig. 2

From: A novel depolymerase encoded by phage P5054 specifically degrades the K57-type capsular polysaccharide of Klebsiella pneumoniae

Fig. 2

Bioinformatic analysis of the phage P5054 genome and structural characterization of the putative depolymerase K57-Dpo8. A Genomic map of phage P5054, with open reading frame 8 (ORF8, highlighted in red) encoding the predicted polysaccharide depolymerase. B Bioinformatic analysis of the putative depolymerase K57-Dpo8. The tail fiber protein comprises 570 amino acids and contains a predicated domain, the pectate lyase domain (residues 27–436), as identified by BLASTp and HHpred analysis. C Structural modeling of depolymerase K57-Dpo8 using AlphaFold3. D Predicated active-site residues of K57-Dpo8. The 3D structural model of K57-Dpo8, visualized using PyMOL software, is shown in red, while the 3D model of rhamnogalacturonase A (RGase A) is shown in blue. The active-site residues Ala193 and Pro220 in K57-Dpo8 and Asp156 and Asp180 in RGase A are highlighted

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One Health Advances

ISSN: 2731-9970

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